Jobs

Research Associate in Cryopreservation

University: Newcastle University, United Kingdom 
Location: Newcastle upon Tyne, United Kingdom
Closing Date: 14th September 2018 

For informal enquiries please contact Dr. Roman Bauer
View the Job Description and Postdoc Advertisement
Apply online now

An exciting job opportunity as a Postdoctoral Research Associate is available at Newcastle University, between the Institute of Genetic Medicine (IGM) and the School of Computing (CS). The RA will conduct experimental work in a multidisciplinary team, comprising Dr Roman Bauer (CS), Prof. Majlinda Lako (IGM) and Prof. Evelyne Sernagor (Institute of Neuroscience).

You will work on a project studying the impact of cryopreservation on different kinds of biological tissues. Cryogenic processing protocols will be tested and assessed using a wide range of experimental methods, taking into account anatomy, gene expression and electrical activity. The goal of the project led by Dr Roman Bauer, in collaboration with GE Healthcare and CERN, is to model and improve tissue cryopreservation to yield high-quality post-thaw tissue.

You will hold a PhD in a bioscience discipline and have experience in several experimental techniques, which can be for instance immunohistochemistry, primary cell/tissue culture, qPCR and/or pluripotent stem cell differentiation. Ideally, you will also have experience in at least one electrophysiology method, e.g. in patch clamp or multi-electrode array (MEA) recording.

You will be highly ambitious, have excellent written and spoken English language skills, the ability to present clearly your work, supervise students and collaborate efficiently in a multidisciplinary team. You will have the opportunity to learn new experimental techniques (e.g. organoid growth or MEA recordings from retina), develop leadership skills or quantitative or computational skills if you wish.

The post is funded by the Engineering and Physical Sciences Research Council (EPSRC) and tenable for 32 months on a full-time basis. As part of your application, please provide a CV and covering letter which details your prior experience in experimental work.

Cryobiology Post-Doc at CDC Foundation 

Entomologist, Biologist or Cryobiologist, Post Doc
Location: Red River Valley Agricultural Research Center
USDA-ARS, Fargo, ND, USA
Closing Date: February 2, 2018
Link: https://www.cdcfoundation.org/jobs/entomologist-biologist-or-cryobiologist-post-doc-941

The CDC Foundation seeks candidates for a full time post-doctoral entomologist, biologist or cryobiologist position to assist with the development of techniques for the cold storage and cryopreservation of mosquitoes. Such techniques may including preparation of egg or larval stages for cryoprotectants permeation, analysis of cryoprotectant toxicity, and vitrification in liquid nitrogen or nitrogen slush. Ancillary methods will include retrieval from cryopreservation, insect rearing and the effects of thermal history on storage success. This laboratory position works 40 hours a week, some of which may consist of part-time weekend and holiday work. The post-doctoral entomologist, biologist or cryobiologist will be hired by the CDC Foundation and assigned to the United States Department of Agriculture (USDA) Agricultural Research Service (ARS) Red River Valley Agricultural Research Center on the campus of North Dakota State University in Fargo, North Dakota.

For more information, including how to apply, download the job specification.  

Senior Engineer in Cancer Immunotherapy 

Company: Kite
Location:
Santa Monica, CA, USA
Closing Date:
Open until filled

Kite, a Gilead company, is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors.

Kite is seeking a highly motivated individual with fill finish and cryopreservation process engineering experience to work on innovative T cell therapy for cancer treatment. The Senior Engineer will demonstrate deep knowledge of fill finish and cryopreservation, develop robust processes for final drug product formulation, fill finish and cryopreservation for T cell therapy. The Senior Engineer will work with the Early Stage Product Sciences team to design, establish and scale-out cell therapy processes to support early phase clinical trials, manage equipment qualification and support process verification, draft and review protocols, production procedures, process development reports, and provide technical assessment and approval for engineering and process changes pertaining to fill finish and cryopreservation. The Senior Process Engineer will also participate in laboratory activities to support process development and process characterization of Kite’s autologous T cell products.

Download the Job Specification

Graduate student research positions at University of Saskatchewan

Student Positions in reproductive biology, biophysics, and mathematical biology.

Prof. James Benson (Cryobiology Laboratory) in the Department of Biology at the University of Saskatchewan is seeking four new graduate student researchers in Cryobiology, with an emphasis in fundamental cryobiology of reproductive cells and tissues.

Prof Benson’s research focuses on biophysical/biochemical modeling to rationally address the mechanisms of damage accrued during cryopreservation. All students will be trained in both benchtop lab work and computer modeling, and research programs can be tailored to best fit a student’s interest and desired outcomes.

Specifically, there are four openings:
Two M.Sc. or Ph.D. students who will focus on mitigation of cryopreservative solution toxicity in oocytes. These projects will provide students with access to novel experimental apparatuses and control systems. These students will be jointly supervised by Dr. Benson and Muhammad Anzar (Western College of Veterinary Medicine) or Jack Gray (Biology Department). All undergraduate majors are welcome to apply. Those with some experience at the intersection of biology and mathematics/computational modeling are preferred.





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Organ Preservation Postdoc 

Job Title: Postdoctoral Fellow
Location: Center for Engineering in Medicine
Massachusetts General Hospital & Harvard Medical School  
Closing date: December 2017

CEM is affiliated with Massachusetts General Hospital & Harvard Medical School & Shriners Hospital and houses 6 senior and ~10 junior PIs along with  a research staff >50; it’s also the home to the BioMems Resource Center . The research in the hospital is funded by NIH, NSF, DOD, Shriners, MGH as well as industry.

 More info on CEM can be found at http://www.massgeneral.org/cem/ and http://cem.sbi.org/web/index.htm

Description: We are looking for a talented Postdoctoral Fellow to contribute to our work on whole organ preservation for the purpose of transplantation.

Description of the project: The field of transplantation is facing a serious donor shortage crisis. The World Health Organization estimates organ transplants are meeting less than 10% of global demand. Of critical importance, the field of transplantation suffers from ineffective bio-preservation and stabilization protocols resulting in a short amount of time - currently hours - which organs can be kept alive ex vivo. This creates an inherent bottleneck in the system: most directly, improvement of current organ preservation practices has the potential to improve organ quality, enabling the use of currently discarded organs, decreasing the incidents of graft failure, and extending the in vivo lifetime of the transplanted organ. Further, longer storage durations would enable HLA typing and global matching programs, therefore improving transplantation outcomes, and reducing the burden of immunosuppressive therapy. Similarly, extending ex vivo organ preservation duration will allow for more complete quality control analyses thereby providing more time for complex clinical decisions, reducing unnecessary waste of quality organs, and alleviating concerns about disease transmission between donor and recipient.

Desired Skills and Experience: We are looking for highly motivated and hardworking Postdoctoral Fellows with diverse backgrounds to join our highly interdisciplinary team. Example tasks include (but are not limited to) operation of machine perfusion equipment, solution formulation, cell culture, microscopy and histology, and molecular assays (e.g. ELISAs, qPCR, etc.). The candidate will be supervised by faculty or senior research staff, will be involved in research projects, and expected to contribute and lead research papers.

Expertise in cryobiology, drug delivery, nanotechnology, or biomaterials are examples of highly desirable skills. Also, experience with perfusion technology, live animal handling, cell culture, and molecular assays are added benefits.  

Contact Person: Applications should be sent to both [email protected] (Dr. Mehmet Toner) and [email protected] (Dr. Korkut UYGUN) with the subject line “Postdoc: Organ preservation”.

Postdoc at Stanford University 

Postdoc position for millimeter-scale cryofluidic systems
Stanford University 
Applications accepted until position is filled. 
 
We are seeking a joint postdoctoral fellow or research engineer to help develop millimeter-scale cryofluidic systems for working with and handling functional biomaterials (i.e., cells, cultures, environmental samples). Ideal candidate should be able to work independently, and also with a diverse team of scientists, engineers, and designers to rapidly prototype and iterate on the design and testing of integrated systems (i.e., build a 'box', test a 'box', debug and repeat). Expertise and prior experience in working with fluids in low temperature systems (e.g., -80C) and interfacing low temperature fluidic systems to other mechanical and electronic systems strongly desired. 
Please contact Sindy Tang (Mechanical Engineering, [email protected]) and Drew Endy (Bioengineering, [email protected]) if available and interested along with 1) your CV, 2) a statement describing why you are interested and qualified for the position, and 3) a list of names and contact information of references.

Research Specialist Vacancy Missouri-Columbia

Vacancy: Research Specialist
Location: University of Missouri-Columbia
Closing Date: Open until filled 

We have an immediate opening to join our collaborative team as a member of the rodent reproductive and cryopreservation laboratory of the NIH-funded Mutant Mouse Resource and Research Center (MMRRC) and Rat Resource and Research Center (RRRC) located at the University of Missouri
-Columbia.  

Individuals must have a BS and/or post-BS degree at any level 
in an appropriate area of life science (i.e., Biology, Animal Science, Medical Technology, etc.)  A minimum of one (1) year of laboratory-related experience is necessary.  Experience with cell culture, microscopy, surgical procedures and/or reproductive biology is preferred. 

The responsibilities of the position include sperm and embryo cryopreservation; surgical procedures such as embryo transfer and vasectomy; media and hormone preparation; animal injections; data collection and inventory management; preparation of laboratory protocols; and other duties as may be assigned. 

The position requires an exceptional attention to detail, the ability to handle rodents, intensive microscope work and good manual dexterity with a high degree of technical accuracy.  While skills in gamete and embryo micromanipulation are desired, we will train the right individual.  Applicants should be comfortable working as part of an interdisciplinary team and must have excellent communication skills.

This is a full-time, benefit-eligible position and may require some weekends and holiday rotations. 
The University of Missouri is an equal opportunity employer.

To apply for this position:   Job Opening ID (23744) Research Specialist I  











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Postdoc Position for Bull Semen Cryopreservation Optimization

The Benson Cryobiology laboratory at the University of Saskatchewan, in collaboration with SEMEX, Inc in Quebecc, is offering a 2-year postdoctoral fellowship to an applicant interested in using novel interdisciplinary techniques to optimize bull semen cryopreservation. The successful candidate will work towards bull semen cryopreservation media optimization by determining biophysical parameters, cryoprotectant toxicities, and toxicity minimizing agents. Then they will use these components in a novel way to determine optimal cryoprotectant media equilibration protocols leading to successful post thaw recovery. This interdisciplinary project combines basic sperm science with mathematical modeling and optimization in an applied setting with access to large donor, recipient, and data pools.

Qualifications:

  • Candidate must be within 6 months of completing their Ph.D. degree in a discipline related to theriogenology or cryobiology.
  • Candidate must have at least one first author publication in the area of mammalian sperm, preferably in sperm cryopreservation.
  • Knowledge of cryobiological principles and sperm preservation techniques is preferred but not required.
  • Candidate must be comfortable with, but not necessarily expert in, mathematical modeling approaches to biology.
  • Candidate must be willing to travel between two principal locations (Saskatchewan and Quebec).

To apply:
Please send a cover letter describing your research interests, research experience, and career goals, as well as a copy of your CV and contact information for three references to: Dr. James Benson at james.benson[at]usask.ca. 



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