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CRYO2017 Special Report

A guest post by Fazil Panhwar, student member of the Society for Cryobiology and member of the local organizing committee of CRYO2017. 

Fazil is a Masters student, studying with Society for Cryobiology Governor Professor Gang Zhao, at the University of Science and Technology of China (USTC) in Hefei. In addition to his studies, Fazil has been an integral member of the local organizing committee and also led the organization of the ICYR activities. He shares his unique perspective and insights into CRYO2017 in this special report. 

CRYO2017 “The World Cryobiology and Biobanking Conference” was successfully hosted by University of Science and Technology of China.






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Getting Social at CRYO2017!

After the science wrapped up at CRYO2017, the local organizers arranged a banquet of traditional Chinese fare, including potent local spirit Baijiu. After dinner the student award winners were announced and our outgoing board members recognized for their service to the Society.

Over the following few days a variety of tours were offered by the local organizing committee, including tours to Lake Chaohu, Sanhe Village, an ancient water village, and Mount Huangshan and Hongcun Village, a UNESCO world heritage site. 

Click the thumbnails below to view the high res image. 

CRYO2017 Banquet - Photos by Xuexun Zhou
 
ISBER at CRYO2017:Brent Schacter, Jason Acker, Kathy 
Sexton, Bill Grizzle, Ana Torres, Zisis Kozlakidis, Lynsey
Mellon, Dayong Gao.

 
Society for Cryobiology President and President-Elect, 
Jason Acker and Dayong Gao, with Miao Zhang, student
member. 









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ICYR at CRYO2017

The International Cryobiology Youth Researchers (ICYR) had a busy week at CRYO2017 with two social events and the opportunity to actively participate in learning how to chair a session during a symposium. 

On Saturday July 22 the ICYR held a dinner at the Fengda Hotel, which featured a range of Anhui province and other Chinese specialities. The food was an almost endless array of meat and fish and a number of us tasted chicken feet for the first time. Verdict: Spicy and less weird than expected! 

On Sunday afternoon the ICYR visited Anhui Museum and Maan Coffee Corner, a popular Hefei cafe. Special thanks to Fazil Panhwar, a graduate student of the University of Science and Technology of China, and member of the local organizing committee, who organized these two events. 

Students this year also had the chance to apply to become a student moderator. This initiative, started by the ICYR at CRYO2016, was so popular, we have decided to make it a regular feature of the ICYR activities. It gives students the opportunity to learn how to moderate a conference session in a hands on way, led by one or two experienced mentors.

If you'd like to take part in next year's ICYR activities in Madrid or enter the student awards and grants, make sure you renew your student membership for 2018 and keep an eye on facebook and your email for details in early 2018. Applications for the student awards and grants will be due at the end of March 2018, with the ICYR deadlines closer to the beginning of the meeting. 

Click the collage below for the high res image. 







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Organ Banking Summit Event Report

Guest Post by Jason Acker, President of the Society for Cryobiology. 


Above: Society for Cryobiology board members: Rob Ben, Governor; Gloria Elliott former Treasurer and Governor; Jason Acker, President.

Scientists, engineers, key stakeholders from government, and industry and leaders from non-profit organizations focused on organ procurement for human health came together in Boston from Aug 3-6, 2017 for the Summit on Organ Banking through Converging Technologies (i.e. the Organ Preservation Summit). The Society for Cryobiology partnered with the Organ Preservation Alliance to host this exciting event aimed at bringing together experts to discuss the need for advances in organ banking and how best to overcome the scientific challenges that will enable long-term organ preservation.


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Click the image below to view in high res. 

Organ Preservation Postdoc 

Job Title: Postdoctoral Fellow
Location: Center for Engineering in Medicine
Massachusetts General Hospital & Harvard Medical School  
Closing date: December 2017

CEM is affiliated with Massachusetts General Hospital & Harvard Medical School & Shriners Hospital and houses 6 senior and ~10 junior PIs along with  a research staff >50; it’s also the home to the BioMems Resource Center . The research in the hospital is funded by NIH, NSF, DOD, Shriners, MGH as well as industry.

 More info on CEM can be found at http://www.massgeneral.org/cem/ and http://cem.sbi.org/web/index.htm

Description: We are looking for a talented Postdoctoral Fellow to contribute to our work on whole organ preservation for the purpose of transplantation.

Description of the project: The field of transplantation is facing a serious donor shortage crisis. The World Health Organization estimates organ transplants are meeting less than 10% of global demand. Of critical importance, the field of transplantation suffers from ineffective bio-preservation and stabilization protocols resulting in a short amount of time - currently hours - which organs can be kept alive ex vivo. This creates an inherent bottleneck in the system: most directly, improvement of current organ preservation practices has the potential to improve organ quality, enabling the use of currently discarded organs, decreasing the incidents of graft failure, and extending the in vivo lifetime of the transplanted organ. Further, longer storage durations would enable HLA typing and global matching programs, therefore improving transplantation outcomes, and reducing the burden of immunosuppressive therapy. Similarly, extending ex vivo organ preservation duration will allow for more complete quality control analyses thereby providing more time for complex clinical decisions, reducing unnecessary waste of quality organs, and alleviating concerns about disease transmission between donor and recipient.

Desired Skills and Experience: We are looking for highly motivated and hardworking Postdoctoral Fellows with diverse backgrounds to join our highly interdisciplinary team. Example tasks include (but are not limited to) operation of machine perfusion equipment, solution formulation, cell culture, microscopy and histology, and molecular assays (e.g. ELISAs, qPCR, etc.). The candidate will be supervised by faculty or senior research staff, will be involved in research projects, and expected to contribute and lead research papers.

Expertise in cryobiology, drug delivery, nanotechnology, or biomaterials are examples of highly desirable skills. Also, experience with perfusion technology, live animal handling, cell culture, and molecular assays are added benefits.  

Contact Person: Applications should be sent to both mehmet_toner@hms.harvard.edu (Dr. Mehmet Toner) and uygun.korkut@mgh.harvard.edu (Dr. Korkut UYGUN) with the subject line “Postdoc: Organ preservation”.

Postdoc at Stanford University 

Postdoc position for millimeter-scale cryofluidic systems
Stanford University 
Applications accepted until position is filled. 
 
We are seeking a joint postdoctoral fellow or research engineer to help develop millimeter-scale cryofluidic systems for working with and handling functional biomaterials (i.e., cells, cultures, environmental samples). Ideal candidate should be able to work independently, and also with a diverse team of scientists, engineers, and designers to rapidly prototype and iterate on the design and testing of integrated systems (i.e., build a 'box', test a 'box', debug and repeat). Expertise and prior experience in working with fluids in low temperature systems (e.g., -80C) and interfacing low temperature fluidic systems to other mechanical and electronic systems strongly desired. 
Please contact Sindy Tang (Mechanical Engineering, sindy@stanford.edu) and Drew Endy (Bioengineering, endy@stanford.edu) if available and interested along with 1) your CV, 2) a statement describing why you are interested and qualified for the position, and 3) a list of names and contact information of references.

Research Specialist Vacancy Missouri-Columbia

Vacancy: Research Specialist
Location: University of Missouri-Columbia
Closing Date: Open until filled 

We have an immediate opening to join our collaborative team as a member of the rodent reproductive and cryopreservation laboratory of the NIH-funded Mutant Mouse Resource and Research Center (MMRRC) and Rat Resource and Research Center (RRRC) located at the University of Missouri
-Columbia.  

Individuals must have a BS and/or post-BS degree at any level 
in an appropriate area of life science (i.e., Biology, Animal Science, Medical Technology, etc.)  A minimum of one (1) year of laboratory-related experience is necessary.  Experience with cell culture, microscopy, surgical procedures and/or reproductive biology is preferred. 

The responsibilities of the position include sperm and embryo cryopreservation; surgical procedures such as embryo transfer and vasectomy; media and hormone preparation; animal injections; data collection and inventory management; preparation of laboratory protocols; and other duties as may be assigned. 

The position requires an exceptional attention to detail, the ability to handle rodents, intensive microscope work and good manual dexterity with a high degree of technical accuracy.  While skills in gamete and embryo micromanipulation are desired, we will train the right individual.  Applicants should be comfortable working as part of an interdisciplinary team and must have excellent communication skills.

This is a full-time, benefit-eligible position and may require some weekends and holiday rotations. 
The University of Missouri is an equal opportunity employer.

To apply for this position:   Job Opening ID (23744) Research Specialist I  











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CRYO2017 Report

CRYO2017: The World Cryobiology and Biobanking Conference drew to a close July 23, 2017 after three very busy days of the latest scientific research. The meeting was jointly hosted by the Society for Cryobiology and the China Medicinal Biotech Association and took place at Fengda International Hotel in Hefei, Anhui Province, China.

The meeting was one of the largest in recent memory with over 500 delegates in attendance and was an excellent introduction to the Society for Cryobiology for the local delegates from China.

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Congratulations to our Student Award Winners


In 2017 the Society for Cryobiology awarded over $12,000 to our student members in travel grants and prize money. 



Above: All Student Prize Winners and Travel Grant Awardees
Back Row: James Benson, Chair of the Awards Committee; Ilya Savchenko (Israel); Ross Warner (USA); Krishna Ramajayam (India). 
Front Row: Dayong Gao, President-Elect, Society for Cryobiology and Co-Chair of CRYO2017; Nikola Dolezalova (UK); Chandrika Kumari (India); Wenhui Li (China); Krishnaa Mahbubani (UK); Kezhou Wu (China); Jason Acker, President, Society for Cryobiology. 
Not pictured: Wei Di (China); Maryam Hezavehei (Iran); Xueru Jiang (China); Jiaji Pan (USA). 

Each year the Society for Cryobiology invites student members to submit an extended abstract to be considered for a number of awards including the prestigious Crystal Award for best student oral presentation, the Critser Travel Award, sponsored by the family of late cryobiologist John K. Critser, and a large number travel grants to attend the Society's annual meeting in order to present their research. All students presenting a poster at the meeting are also eligible to enter the Best Poster Award. 

Above: Peter L. Steponkus Crystal Award Finalists: James Benson, Chair of Awards Committee; Ross Warner (USA), Maryam Hezavehei (Iran); Nikola Dolezalova (UK); Jiaji Pan (USA). 











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Dayong Gao Elected to Academy of Sciences

Society for Cryobiology President-Elect, Dayong Gao of the University of Washington, has been elected to the Washington State Academy of Sciences (WSAS). 

The WSAS is a non-profit state resource for the government, organizations and citizens relating to science, technology, health, and the environment, and aims to inform public policy decision making in Washington State. 

Currently comprising 267 members, the WSAS elects only the state's most distinguished scientific and technical experts.

Gao fulfils these criteria through his contributions in the field of cryobiology and the science and technology of artificial organs. His work impacts the development of cutting-edge biotechnology that treats diseases, organ failure, and contributes to species conservation worldwide.

Welcome to our Newest Members

Welcome to the following new members! 

Japan
Mr. Kyohei Yamashita - Student Member 

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Ross Warner Wins Critser Award 

Ross Warner has been named the Critser Award winner for 2017.

The Critser Award is sponsored by the family of late cryobiologist and former President of the Society for Cryobiology, John K. Critser. The award recognizes the best extended abstract submission by a student and carries an honorarium of $1500 USD to attend the annual meeting, taking place this year in Hefei, China July 21-23.  

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GE Healthcare Purchases Asymptote

GE Healthcare has recently purchased Asymptote. Founder and CEO of Asymptote, John Morris, is a long time member of the Society for Cryobiology. 

From the press release

Asymptote’s integrated suite of cryochain hardware, software and consumables are designed to maintain the potency of cellular therapies enabling ultra-low temperature freezing during production, all the way to thawing at the clinic prior to administering to patients. The acquisition of Asymptote fills a critical gap in GE Healthcare’s end-to-end ecosystem of products and services for cell therapy production, and will be an important piece of the portfolio enabling the industrialization of these life-saving therapies.


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Miao Zhang Defends Thesis 

Student member of the Society for Cryobiology, Miao Zhang, is to defend her thesis on June 23, 2017. During her PhD studies Ms. Zhang received the Society's John K. Critser award for the best extended student abstract in 2015 and the Peter L. Steponkus Crystal award for the best student oral presentation at the Society's meeting in 2016.

Thesis: Towards dry preservation of mammalian cellls
The central aim of this thesis was to test if trehalose can be introduced into mammalian cells during freezing-induced membrane permeabilization and if this subsequently stabilizes cells during freezing and/or freeze-drying. It was hypothesized that membrane-impermeable molecules including trehalose can be loaded into cells through freezing-induced membrane phase transitions. One of the conclusions was that mammalian cells can be loaded with membrane-impermeable compounds (i.e. trehalose) by subjecting the cells to freezing-induced osmotic stress and membrane imperfections. It was shown that trehalose can be used as sole cryoprotectant to cryopreserve cells. Preloading with trehalose via fluid-phase endocytosis did not increase cryosurvival rates if trehalose is also added as extracellular protectant. It is particularly freezing-induced trehalose uptake that facilitates cryosurvival when trehalose is used as the sole cryoprotectant. One other aim was to investigate if freezing-induced uptake of trehalose stabilizes cells during freeze-drying, and to assess the effect of trehalose on storage stability of DNA during freeze-drying and dried storage. No viable cells were recovered after freeze-drying and rehydration. DNA was found to be largely intact directly after freeze-drying. DNA damage in freeze-dried cells progressively increases with storage duration and temperature. DNA damage was prevented by storage of the samples at 4°C. It was shown that trehalose reduces DNA damage during storage.

Biography
Miao Zhang received her education at Southeast University (Nanjing, China) (BE, 2011), after which she completed master's studies at Ulm University (Ulm, Germany) (MSc, 2013). She was accepted in the PhD program ‘Regenerative Sciences’ in 2013 at Hannover Medical School (Hannover, Germany) and conducted her PhD project at the Institute of Multiphase Processes, Leibniz University of Hannover (Hannover, Germany), under the supervision of Dr. Willem Wolkers. 

Searching for Outstanding Individuals 

The Society for Cryobiology established the award and medal of CryoFellow over a decade ago in recognition of members of the society and individuals from the cryobiology community who have had an outstanding impact on the field.

Newly appointed fellows are presented with the prestigious Basile. J. Luyet medal at the annual meeting the Society for Cryobiology in recognition of their services to cryobiology. Recent Fellows have included Greg Fahy and John Bischof (2016) and Kenneth Diller (2015). 

The Fellow Committee is now inviting annual nominations of outstanding individuals to be considered as Fellows of the Society for Cryobiology.

CryoFellows are awarded this prestigious status in recognition of:



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Notes From the Director's Desk 

At a glance, here's everything you need to know about CRYO2017!

Submissions

The 54th Annual Meeting of the Society for Cryobiology, CRYO2017 in the city of Hefei, Anhui Province, China on July 21 - 23, 2016 at the super 5-star business Fengda International Hotel is really taking shape with over 184 confirmed oral and poster presentations.
 This total includes 63 student abstracts and features 719 authors from 19 different countries. These include submissions from China, the USA, the UK, Canada, and as far afield as Iran, Russia, Australia, Bangladesh, Peru, and many others. The abstracts are currently being streamed into a fantastic scientific program typical of this premier event in the field of cryobiology, and the final program will be available soon. 


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Peter Mazur Memorial Website 

Fritz Kleinhans has recently unveiled a memorial website for the late Peter Mazur. Fritz has invited members of the Society for Cryobiology to submit photographs or remembrances for inclusion on the site. 

Peter Mazur (1928-2015) was a pioneer and leading figure in the world of cryobiology for over 50 years. He was a founding member of the Society for Cryobiology and served as President from 1973-1974. He served numerous terms as Governor and was active at board meeting even while not in office (no one argued with Peter!). He was also a member of the editorial board from 1967 until his death.

Close friends and colleagues of Peter's, Fritz Kleinhans and David Pegg, wrote a touching obituary which was published in the April 2016 issue of Cryobiology. The obituary, along with photos and details of Peter's most important research can all be found on the memorial website.  

New Member Welcome

Since our March quarter newsletter the society has welcomed 26 new student and individual members from around the world and one new institutional member, The Biobank of Picardie

Welcome to the Society for Cryobiology! 

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Do you have what it takes to govern the Society for Cryobiology?  

Nominations are now open for the following posts:

  • President-Elect (2018-2019)
  • Secretary (2018-2019)
  • Treasurer (2018-2019)
  • 3 Governors (2018-2020)

As part of the Society's move to a more open and transparent system of election and governance, the Board of Governors is now inviting nominations from all Society members in good standing for the officer and governor posts detailed above.

To declare your candidacy please email a detailed biography and candidate statement outlining your vision for the Society to Nicole Evans by August 1, 2017.

If you have any questions or would like to discuss the roles and their responsibilities please don't hesitate to contact me at nicole.evans@beds.ac.uk

Please note all nominations are subject to final approval by the nominations committee. This does not affect your right to nomination by petition as outlined in the society's bylaws